RAF Typhoon FGR4s have operated alongside France's air force in a coordinated attack targeting an subterranean weapons facility in Syrian territory operated by the IS group, according to the British defence ministry.
The facility, located using reconnaissance, was assessed as storing arms and explosives, the release indicated, and was situated in mountainous terrain just to the north of the ancient city of Palmyra in Syria's central region.
"The RAF jets employed laser-guided Paveway IV weapons to target a series of access tunnels down to the facility... initial indications indicate the target was engaged successfully," the ministry announced.
There was no indication of any harm to civilians in the attack late on Saturday and each participating jet returned to base without incident, the defence officials confirmed.
The Typhoon FGR4s were assisted by a Voyager aerial refuelling aircraft.
The Islamic State group - referred to as Daesh - established extremist governance over significant areas in both Syria and Iraq before its territorial defeat in 2019.
"This strike shows British leadership, and resolve to work closely with our allies, to stamp out any revival of IS and their harmful and extremist ideologies in the region," Britain's Defence Chief the Defence Secretary remarked.
British military aircraft have conducted patrols over Syria to "prevent any efforts to regroup" of IS subsequent to its defeat at the battle of Baghuz in 2019, the authorities noted.
"I want to thank the personnel of British forces who took part in this strike for their skill and their bravery," the Defence Secretary commented. "Including them were thousands of British personnel deployed over the holidays. This action, to remove dangerous terrorists who endanger our safety, demonstrates how British military are prepared to act, continuously, keeping Britain secure at home and influential overseas."
In December, the United States armed forces conducted what it termed a "major assault" against Islamic State objectives in Syria, following an assault resulted in the deaths of two American soldiers and a civilian interpreter in the Palmyra area.
The United Nations says IS still has roughly 5-7 thousand militants in Iraq and Syria.